60

0.95

0.90

0.85

0.80

0.75

0.70

0.65

0.60

0.55

0.50

0.45

0.40

0.35

0.30

0.25

0.20

0.15

0.10

0.05

0.00

0

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

time

0.95

0.90

0.85

0.80

0.75

0.70

0.65

0.60

0.55

0.50

0.45

0.40

0.35

0.30

0.25

0.20

0.15

0.10

0.05

0.00

0

1

2

3

4

5

6

7

8

9

10

time

Hypertrophic

Stimulus

ERKTEY-

Phosphorylation

Elk 1 +

MSK1 +

C-Myc

p90RSK+

p70S6K

ERKThr188-

Phosphorylation

Mitogenic

stimulus

ERK TEY-

Phosphorylation

p90RSK +

p70S6K

NFAT

NFAT

 

5.1

(continued)

5  Systems Biology Helps to Discover Causes of Disease